Overlapping alterations at chromosome 10 in one chRCC and two cases of RO defined two common regions, namely a 1.5 Mb region within 10q11.23-q21.1 (ACF, D45864, PRKG1 and CSTF2T) and a 2.5 Mb region within 10q21.1 (ZWINT). Here, PRKG1 is linked to chromophobe renal cell carcinoma.