Mean BNP level at admission of 81 patients in the CKD + ADHF group was higher than that in the CKD - ADHF group (2708.6 ± 1246.9 pg/ml vs. 567.9 ± 491.7 pg/ml, P = 0.000) and was also higher than that in the control group (1418.9 ± 1126.5 pg/ml, P = 0.000; Figure 1a). Here, NPPB is linked to chronic kidney disease.