We provide evidence of MLL and SEPT2 down-regulation in MLL-SEPT2 myeloid neoplasia, as well as MLL under-expression in AML with MLL fusions with other partners other than SEPT2 but, due to the small number of MLL-SEPT2 cases available, these results should be confirmed in a larger series of patients. Here, KMT2A is linked to acute myeloid leukemia.