They found that wild type PIP5K2A, but not the schizophrenia-associated mutant (N251S)-PIP5K2A, was able to activate the heteromeric KCNQ2/KCNQ3 and KCNQ3/KCNQ5 channel complexes that make up the neuronal voltage-gated potassium M channels. This evidence concerns the gene KCNQ3 and schizophrenia.