BCL2 and chondrosarcoma: While the untreated chondrosarcoma cells exhibited chemoresistance, Bcl-2, Bcl-xL and XIAP gene silencing enhanced chemosensitivity by up to 2.7 fold (XIAP siRNA treated JJ012: 9.97 ± 1.47%, p < 0.05) at 0.1 μM and 3.3 fold (Bcl-xL siRNA treated JJ012: 16.90 ± 3.84%, p < 0.01) at 1 μM in comparison to each nonsilencing control group (JJ012: 3.63 ± 1.27% at 0.1 μM, 5.12 ± 1.49% at 1 μM) on flow cytometric examination (Figure 7A and 7B).