The ALT remained elevated, and 16 months after randomization he was admitted to hospital with severe acute hepatitis (ALT >1000 U/L, AST = 1728 U/L [ULN 42 U/L] and bilirubin = 459 μmol/L [ULN 17 μmol/L]). The gene discussed is GPT; the disease is Acute hepatitis.