Most of these elevations were not confirmed at these early recall visits despite continued treatment: overall, ALT >3 × ULN on repeat testing was found in only 21 patients in the simvastatin group compared to 9 in the placebo group (0.20% vs 0.09%; P = 0.045); and of these, only 1 vs 0 were diagnosed clinically as hepatitis. This evidence concerns the gene GPT and hepatitis A virus infection.