However, recent studies have shown that FKBP12.6 may not be involved in Ca2+ release from the sarcoplasmic reticulum, since the loss of FKBP12.6 has no significant effect on the conduction and activation of RyR2 or the propensity for spontaneous Ca2+ release and stress-induced ventricular arrhythmias [12]. This evidence concerns the gene FKBP1B and Ventricular arrhythmia.