We also observed that SALL4 was able to bind the promoter regions of these two genes in either mouse ESCs, two human AML samples including M0 (FAB classification) or AML transformed from CML (chronic myeloid leukemia) using ChIP-on-ChIP assays (data not shown). The gene discussed is SALL4; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.