Two different approaches have been followed to identify mutant p53-associated gene-expression signatures: a) cell lines overexpressing different mutant forms of p53 have been generated to analyze the impact of mutant p53 on cell transcriptome; b) tumor samples with characterized p53 status (mutated or wild-type) have been examined by microarray analysis for their global gene expression. The gene discussed is TP53; the disease is neoplasm.