CASP8 and cancer: Additionally, it was reported that miR-19b-1 may also target caspase 8 (CASP8), death-associated protein kinase 3 (DAPK3), and programmed cell death 1 ligand 2 (PDCD1LG2), all genes known to be involved in apoptosis, further suggesting the anti-apoptotic function of the miR-17-92 cluster in cancer.