Testicular index, indices of semen quality and serum testosterone concentrations of male SCD patients are generally lower than those of men with normal hemoglobin even though circulating follicle stimulating hormone (FSH), luteinizing hormone (LH) and prolactin (PRL) are comparable, indicating hypogonadism among SCD patients [6]. This evidence concerns the gene PLOD1 and Schnyder corneal dystrophy.