Furthermore, in the ApoE knock-out murine model of atherosclerosis, Hp2/Hp2 mice obtained by targeted insertion of a murine type 2 Hp allele into the Hp locus by homologous recombination show increased iron deposition, lipid peroxidation and macrophage accumulation within atherosclerotic plaque, increasing the risk of rupture and thrombosis [30]. This evidence concerns the gene APOE and atherosclerosis.