Promising agents include new non-nicotine-replacement pharmacotherapies [90–93] such as selegiline (a monoamine oxidase type B [MAO-B] inhibitor), fluoxetine (an antidepressant of the selective serotonin reuptake inhibitor [SSRI] class), naltrexone (an opioid receptor antagonist used primarily in the management of alcohol dependence and opioid dependence) and mecamylamine (a ganglionic blocker); other strategies include the development of a vaccine against nicotine dependence [94] and pharmacogenetic approaches to smoking cessation [95, 96]. This evidence concerns the gene MAOB and alcohol dependence.