MET and cancer: The data from previous reports suggest that H. pylori stimulates c-Met phosphorylation in a CagA-dependent manner, and that c-Met is required for H. pylori-induced cancer cell motility.[13, 25] Employing shRNAs to knockdown c-Met expression, though, we clearly demonstrate that H. pylori does not require c-Met to stimulate a motile phenotype in at least two different cell-lines.