These findings suggest that observed changes in Ktrans due the systemic infusion of bradykinin B2 agonists may be independent of RG-2 glioma tumor volume and location, and instead a reflection of bradykinin B2 receptor agonist-mediated systemic hemodynamic changes on local transvascular flow rate across the BBTB, irrespective of brain tumor volume and location. The gene discussed is BDKRB2; the disease is central nervous system cancer.