The statistically significant increase in Ktrans of the BBTB of anterior RG-2 gliomas that we observed with intravenous Met-Lys-BK infusion would be attributable to the combination of: (1) a higher affinity than labradimil for the bradykinin B2 receptors over-expressed on tumor microvasculature and thereby, greater ability to vasodilate tumor microvasculature and increase the permeability of the BBTB; and (2) the lesser metabolic stability than labradimil resulting in a less significant fall in MABP than that caused by labradimil infusion. This evidence concerns the gene BDKRB2 and neoplasm.