Based on pharmacokinetic modeling of the 2nd Gd-DTPA bolus concentration curve data and determination of the tumor vascular parameters during the intravenous infusion of either NS or bradykinin B2 receptor agonist, the percent change from baseline in the vascular parameters of anterior and posterior RG-2 glioma tumor tissues was calculated for each treatment group. The gene discussed is BDKRB2; the disease is central nervous system cancer.