In the case of Ktrans, we found that there was a significant percent change in Ktrans of the BBTB of anterior brain RG-2 gliomas (F4,36 = 11.62, p < 0.0001) and posterior brain RG-2 gliomas (F4,35 = 5.38, p = 0.0017) due to the infusion of bradykinin B2 receptor agonists. This evidence concerns the gene BDKRB2 and central nervous system cancer.