HMGCR and diabetes mellitus: A recent meta-analysis examined whether statins (HMG-CoA reductase inhibitors) are as beneficial in preventing cardiovascular events in patients with diabetes as they are in those without, and found that in patients with diabetes there was a 9% proportional reduction in all-cause mortality per mmol/l (~40 mg/dl) reduction on LDL cholesterol, a reduction similar to the 13% reduction seen in patients without the disease [2].