Constitutive over-expression of Stat1 and Stat1-dependent genes is associated with protection of tumour cells from genotoxic stress following treatment with fludarabine (Friedberg et al. 2004), doxorubicin (Thomas et al. 2004), cis-platinum (Roberts et al. 2005) and the combination of ionising radiation and doxorubicin (Rickardson et al. 2005, Fryknas et al. 2007). The gene discussed is STAT1; the disease is neoplasm.