Taken together, the data imply that, in patients with gallstones, the inflammation and chronic cholelithiasis had particularly stimulated the generation of cytotoxic CD4+P+ cells, decreasing simultaneously the circulating levels of CD8+P+ T cells and CD16+P+ NK cells (Figures 3, 4, 6, and 7), probably owing to their greater homing into the insulted liver tissue. The gene discussed is CD8A; the disease is gallstones.