The data, however, clearly showed that lymphatic subpopulation (CD3, CD4, CD16 and CD56) of patients undergoing the classic cholecystectomy contained, preoperatively, the higher quantities of perforin in their granules in comparison with patients selected for LC (Figures 5(a), 5(b), and 6). The gene discussed is CD4; the disease is laryngotracheoesophageal cleft.