PRF1 and inflammatory bowel disease: Furthermore, since cholestatic jaundice is often followed by bacteriemia [22, 23], for our data showing the correlation of CD4+P+ cells with the serum levels of CRP and AP (Figures 7 and 8) might be relevant that in inflammatory bowel diseases with uncontrolled immune responses to bacterial flora were found CD4 (+) NKG2D (+) T-cell clones that were involved in perforin-mediated killing of the targets expressing MICA [31].