While to our knowledge there has been no study comparing the cytokine response of CD8 T-cells at a single cell level in LTBI subjects and patients with active TB, a recent study on the CD4 T-cell response to Esat-6 and CFP-10 reported that there was a shift in the IFN-γ and IL-2 cytokine profile, notably from a dominance of IFN-γ-only T-cells in active tuberculosis to a dominance of IFN-γ/IL-2-double secreting T-cells [18]. This evidence concerns the gene CD4 and tuberculosis.