Altogether, these results indicate that (a) the frequencies of Mtb epitope-specific CD8 T-cells during active pulmonary TB disease in adults are lower than in LTBI individuals, but that they increase after anti-mycobacterial therapy; (b) that between 50 and 100% of epitopes selected are recognized by individuals with latent or active Mtb infection, including two new epitopes (Rv1490 and Rv1614) and (c), that there appears to be an immunodominance hierarchy in the recognition of different epitopes of Mtb in individuals with LTBI, as well as in patients with active TB before and after therapy. This evidence concerns the gene CD8A and tuberculosis.