The data here reported also point to qualitative differences between TB patients and LTBI subjects in their antigen-specific CD8 T-cell compartment: while approximately 60% of antigen-specific CD8 T-cells in LTBI expressed a terminally-differentiated phenotype (CD45RA+CCR7−), in TB patients this was only 35% of antigen-specific CD8 T-cells. The gene discussed is CCR7; the disease is tuberculosis.