To determine the ex vivo frequency of peptide-specific CD8 T-cells, PBMC from HLA-A*0201 patients with active TB before (T0) and after four months of chemotherapy (T4) and individuals with LTBI were stained with HLA-A*0201/tetramers and anti-CD8 antibody and analysed by FACS. This evidence concerns the gene HLA-A and tuberculosis.