Our results show that while in subjects with LTBI there was a high percentage of IL-2+/IFN-γ+ and IL-2−/IFN-γ+ peptide-specific CD8 T-cells, the IL-2+/IFN-γ+ population was consistently reduced in TB patients, highly suggestive of a restricted functional profile of Mtb-specific CD8 T-cells during active disease. This evidence concerns the gene IL2 and tuberculosis.