Increased plasma IL-6 is an independent risk factor for many diseases associated with aging, including type 2 diabetes, atherosclerosis, hypertension, frailty, and cardiovascular ischemia, and is a significant predictor of delirium, psychosis, stroke, transition from mild cognitive impairment (MCI) to Alzheimer's disease (AD)[3], [7], and progression of AD in older individuals[2], [3]. Here, IL6 is linked to early-onset autosomal dominant Alzheimer disease.