FBN1 and fragile X syndrome: We have evaluated our approach on four data sets: (1) fragile X syndrome (FXS) [11] caused by mutation of FMR1 (fragile X mental retardation 1), (2) Marfan syndrome (MFS) [12] caused by mutation of FBN1 (fibrillin 1), (3) cystic fibrosis (CF) [13] caused by mutation of CFTR, and (4) Becker muscular dystrophy (BMD) [14] caused by mutation of DMD.