In contrast, in PINK infected mice the cells displayed a biphasic production pattern: 28–48% of the cells stained positive for Granzyme B during the first 9 days of infection; between day 14 and day 21pi, only 1–2% of the cells were positive (notably, during this period cells display a central memory phenotype); and by day 28pi, cells had reacquired the capacity to produce Granzyme B. We next measured degranulation by cell surface modulation of CD107a (LAMP-1). The gene discussed is GZMB; the disease is infection.