HIF1A and cancer: Cox regression univariate analysis revealed a significant effect of HIF-1α positivity on cancer-specific survival (Figure 7A; log-rank test χ2=12.2, d.f.=1, HR=5.47 95% CI: 1.96–16.03, P<0.002) and disease-free survival (Figure 7B; log-rank test χ2=10.85, d.f.=1, HR=4.47, 95% CI: 1.68–11.89, P=0.003).