The expression of CXCR3 receptors by CRC human tissues and by the human HT29 cells and the murine C26 tumour cells has led us to determine the ability of the corresponding ligands, CXCL9, CXCL10 and CXCL11 to affect the growth and chemotactic responses of HT29 and C26 cells in vitro. The gene discussed is CXCL10; the disease is colorectal carcinoma.