To reach an understanding of the role played by CXCR3 in colon cancer metastasis to liver and lung, we first analysed the direct function of CXCR3 on the tumour cells in vitro before assessing its involvement in the implantation and the progession of colon carcinoma within the two main target organs in vivo. Here, CXCR3 is linked to colon carcinoma.