The conclusion that faster growing T-ALL cell lines are more GC resistant is supported by studies demonstrating that proliferating human peripheral T lymphocytes are more resistant to DEX than those that are growth arrested (Gilardini Montani et al, 1999; Lopes et al, 2007), and that the GC sensitivity of CCRF-CEM cells can be increased by overexpression of the cell-cycle inhibitor p16INK4A (Ausserlechner et al, 2001). Here, CDKN2A is linked to acute lymphoblastic leukemia.