Although being a receptor for TGFβ, TGFβRIII is also a receptor for inhibins (Wiater and Vale, 2003), and recent studies have reported loss of TGFβRIII as a common and important event in human PCa (Turley et al, 2007; Sharifi et al, 2007a). Here, TGFB1 is linked to posterior cortical atrophy.