HYAL1 and ovarian cancer: Furthermore, HYAL1 transcript levels correlated with hyaluronan content (r = -0.4; P = 0.025) and hyaluronidase activity (r = 0.5; P = 0.006, n = 32), suggesting that HYAL1 dominated the differences in hyaluronidase activity and contributed to the accumulation of hyaluronan in the ovarian cancers.