ERBB2 and malignant colon neoplasm: It could also inhibit the growth of neuroectodermal cancer [17] and breast cancer by suppressing HER-2/neu tyrosine kinase activity in HER-2/neu-overexpressing human breast and lung cancer cells [18-20], inhibit tyrosine-kinase-mediated phosphorylation of vascular endothelial growth factor (VEGF) receptors in colon cancer cells [21], promote the repair of nucleiotide excision to the DNA damage of human cells caused by UV and cislatin induction [22], and finally competitively block the activity of casein kinase II [23].