These include the TPA upregulated genes JunB, Saa3 (serum amyloid A3), Il4Rα (interleukin 4 receptor α), S100a9 (calgranulin B), Rrad (Ras-related associated with diabetes), Krt2-6a (keratin complex 2, basic, gene 6a), and others; as well as TPA downregulated genes such as Doc2γ (double C2, gamma), Aebp1 (AE binding protein 1) and others. The gene discussed is PLAT; the disease is diabetes mellitus.