In the present study, more detailed analysis of manually selected pathways and functional gene sets that are assumed to play a role in paraganglioma formation, i.e. processes of metabolism, angiogenesis and hypoxia as well as proliferation, survival, apoptosis and cell cycle related pathways also did not reveal significant differential expression between sporadic, SDHD -linked and PGL2 -linked paragangliomas. The gene discussed is SDHAF2; the disease is paraganglioma.