All three Akt isoforms have been associated with breast cancer (Bacus et al. 2002; Bellacosa et al. 1995; Nakatani et al. 1999; Perez-Tenorio and Stal, 2002; Stal et al. 2003; Sun et al. 2001a; Sun et al. 2001b; Faridi et al. 2003; Ju et al. 2007). The gene discussed is AKT1; the disease is breast cancer.