Klemke and colleagues were the first to demonstrate that Abl inducible Crk Y221 phosphorylation acted as a molecular switch to dissociate a p130Cas/Crk/DOCK180 ternary complex, in order to block motility and invasive behavior of human pancreatic cancer cells [54] (Figure 4B). This evidence concerns the gene CRK and familial pancreatic carcinoma.