For example, A549 lung adenocarcinoma cells and ECV304 endothelial-derived cells adhering to laminin-10/11 show more robust Rac1 activation compared to these same cells on vitronectin, and further dominant negative Crk proteins that don't interact with DOCK1 block Rac1 activation [55]. The gene discussed is CRK; the disease is lung adenocarcinoma.