CRK and Yersinia pseudotuberculosis infectious disease: A role for Crk in bacterial uptake pathways was first noted by Weidow and colleagues, who demonstrated that Yersinia pseudotuberculosis infection into human epithelial cells activated the p130Cas-Crk-DOCK180-Rac1 pathway via binding of the bacterial invasin to the β1 integrin receptor [63,186].