Since IL-13 is emerging as an important mediator in the development of Th2 cell responses, which can induce IgE secretion from activated human B cells [30] and acts more prominently as a molecular bridge linking allergic inflammatory cells to the non-immune cells [31], we believe that GM-SCF also play a role in acquired immune response such as allergic reactions. The gene discussed is IGHE; the disease is allergic disease.