In the single-center prospective randomized controlled trials from Leuven, the risk of hypoglycemia (glucose of ≤ 2.2 mmol/L or ≤ 40 mg/dL) increased from 0.8% to 5.1% in the surgical ICU trial and from 3.1% to 18.7% in the medical ICU trial.[7,8] In those ICU based trials, insulin adjustments were based on measurements of blood glucose levels in arterial blood, at one- to four-hour intervals, and doses were administered by a team of intensive care nurses, assisted by a study physician. This evidence concerns the gene INS and Hypoglycemia.