RCC is characterized by the loss ofthe von hippel landau (VHL) gene, which leads to dysregulation of the VEGFR,PDGFR-β, transforming growth factor-alpha (TGF-) α, EGFR, and Raf pathways promotingangiogenesis, lymphangiogenesis, tumor cell growth, and survival. The gene discussed is EGFR; the disease is neoplasm.