ERBB2 and neoplasm: Grb7 interacts with many tyrosine kinase receptors, including the epidermal growth factor receptor (EGFR/ErbB1) and others, erytoblastic leukemia viral oncogene homolog receptors (ErbB2, ErbB3, ErbB4) just to give some examples of a set of receptors involved in tumor biology and it has been implicated in cellular migration because of its interaction with focal adhesion kinase (FAK) and the erythropoietin-producing hepatocellular carcinoma cells receptor B1 (EphB1), an ephrin receptor.