The aforementioned Grb7 truncated isoform Grb7V, in which the SH2 domain was substituted by a short hydrophobic tail, was detected in highly invasive human esophageal carcinomas, presenting a particularly enhanced expression in metastasized lymph nodes, underscoring the role of the Grb7 protein in tumor invasion [18]. The gene discussed is GRB7; the disease is neoplasm.