Using primary human normal ovarian surface epithelial and epithelial ovarian cancer cells, it was shown that treatment with Bmp4 increased cellular adhesion, motility and invasion with up-regulation of EMT markers Snail and Slug and with down-regulation of E-cadherin, which are closely relevant to changes in the level of activated Rho GTPases [37]. The gene discussed is BMP4; the disease is ovarian carcinoma.