Profiling of salivary mRNA indicated four major biomarkers of oral cancer including interleukin-1-β (IL1β), interleukin-8 (IL8), ornithine decarboxylase antizyme-1 (OAZ1) and spermidine/spermine N1-acetyltransferase (SAT). The gene discussed is CXCL8; the disease is lip and oral cavity carcinoma.