They found that three out of seven siblings in the family were affected by an AAPC like phenotype with colorectal carcinoma and polyps in the absence of a germline mutation in APC but with somatic mutation of APC characterised by G:C to T:A transversions, suggesting a germline mutation leading to a defect of repair of 8-oxoG-related mutations. Here, APC is linked to colorectal carcinoma.