When males and females were considered separately (Table 2), rs35737219 was associated with visual failure in male LHON patients (p=0.043), When different LHON mutations were studied separately, we observed a significant association between rs45571736 and both m.3460 G>A and m.14484T>C (Table 3, p=0.018 and 0.028 respectively). This evidence concerns the gene MT-ND4 and Leber hereditary optic neuropathy.