Since the encoded inflammatory protein, YKL-40, of CHI3LI seems to be both a marker of inflammation and endothelial dysfunction [5], [17] it is possible that it is the endothelial dysfunction and the later micro- and macrovascular complications of T2D that accounts for the elevated YKL-40 levels in T2D patients. Here, CHI3L1 is linked to endothelial dysfunction.