In contrast to results observed in ISA 70M group, production of IFN-γ decreased in the SjGP-3/CFA, SjGP-3/206 and SjGP-3/1312 groups on week 12 and 15 after infection, with no significant difference in cytokine levels between immunization groups and control group, with the single exception of the CFA adjuvant group on week 12. This evidence concerns the gene IFNG and infection.