ANGPT2 and acute kidney injury: Although this observation does not prove causality, it is in line with a significant association of circulating Ang-2 levels with MAP, and vasopressor requirement in a large cohort of critically ill patients with acute kidney injury (Kümpers P, Hafer C, David S, Kielstein JT, Hecker H, Lukasz A, Fliser D, Haller H, Faulhaber-Walter R, unpublished data).