Furthermore, while initial genotype data from a late-onset AD group and a control cohort failed to demonstrate any association between BACE1 and AD, following stratification for ApoE status it was concluded that a combination of a specific BACE1 allele (within BACE1 codon V262) and ApoE4 may increase AD risk over that attributed to ApoE4 alone [86]. This evidence concerns the gene APOE and Alzheimer disease.