Indeed, we found that Pds5A−/− mice, compared to wildtype mice, had significantly higher incidence of congenital heart defects (17/25 versus 3/18, P<0.001; Fig. 4A–D, See Table S1 in Supplementary Data and Materials S1), including those that are commonly found in CdLS patients [1] and Pds5B-deficient mice [22]. Here, PDS5A is linked to Cornelia de Lange syndrome.