Moreover, CSF BDNF concentration in AD subjects was not different among Met-BDNF genotype G/G (70%, 217±38 pg/ml), G/A (25%, 214±39 pg/ml), or A/A (5%, 213 pg/ml, n = 1) (F = 0.02, df = 2, p = 0.99). This evidence concerns the gene BDNF and Alzheimer disease.