Preventing eIF4F assembly by inhibiting mTOR signalling with rapamycin (Rap) [6], [16] or blocking eIF4F activity with silvestrol, an inhibitor of the ribosome-recruitment step of translation initiation [17], can sensitize Eμ-Myc lymphomas with elevated mTOR signalling to the cytotoxic action of Dxr, though neither of these treatments on their own is effective. The gene discussed is LRPAP1; the disease is lymphoma.