To address whether inhibitors of translation elongation could also synergize with DNA damaging agents (e.g. Dxr), we tested the potential of four elongation inhibitors to modulate chemosensitivity in the Eμ-myc model harboring lymphomas with loss of Pten or Tsc2 or over-expressing Bcl-2 or eIF4E. This evidence concerns the gene PTEN and lymphoma.