VIM and neoplasm: Upregulation of cytosolic vimentin has long been associated with tumor progression and metastasis during the epithelial-mesenchymal transition (EMT) [39], however our findings suggest that increased surface vimentin is also a key feature of tumor endothelium as evident by ability of CPMV to preferentially image these areas [13] and may signal a role for surface vimentin in tumor metastasis or invasion, in addition to cellular adhesion and stress.