ADAMTS1 and age-related macular degeneration: There is possibility that rs2828155 may regulate the expression of these two enzymes, and then the epistasis between rs2828155 and rs1394608 is more straightforward: rs2828155 regulates the enzyme ADAMTS1 and rs1394608 regulates FBLN1. As FBLN1 can act as a cofactor of ADAMTS1 and plays an important role in the degradation of proteoglycans by ADAMTS1 during pathological conditions induced by inflammatory processes [46], it is possible that rs2828155 and rs1394608 have epistatic effect in AMD.