Vegf-C and lymphatic vessel density (LVD) are related to lymph node metastasis (LNM) and poor prognosis of patients in GC, and serum vascular endothelial growth factor-C (SVegf-C) has been recently proposed as a useful biomarker for LNM and prognosis in GC [69]. This evidence concerns the gene VEGFC and metastatic malignant neoplasm in the lymph nodes.